• World Neurosurg · Jun 2018

    Review Meta Analysis

    Association Between Blood Glucose and Functional Outcome in Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis.

    • Jun Zheng, Zhiyuan Yu, Lu Ma, Rui Guo, Sen Lin, Chao You, and Hao Li.
    • Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
    • World Neurosurg. 2018 Jun 1; 114: e756-e765.

    BackgroundIntracerebral hemorrhage (ICH) is a devastating subtype of stroke. Patients with ICH have poor functional outcomes. The association between blood glucose level and functional outcome in ICH remains unclear. This systematic review and meta-analysis aimed to investigate the association between blood glucose level and functional outcomes in patients with ICH.MethodsLiterature was searched systemically in PubMed, EMBASE, Web of Science, and Cochrane Library. Published cohort studies evaluating the association between blood glucose and functional outcome in patients with ICH were included. This meta-analysis was performed using odds ratios (ORs) and 95% confidence intervals (CIs).ResultsA total of 16 studies were included in our meta-analysis. Our data show that hyperglycemia defined by cutoff values was significantly associated with unfavorable functional outcome (OR, 1.80; 95% CI, 1.36-2.39; P < 0.001). Our analysis also suggested a significant association between increased blood glucose levels and functional outcomes (OR, 1.05; 95% CI, 1.03-1.07; P < 0.001).ConclusionsHigh blood glucose level is significantly associated with poor functional outcome in ICH. Further studies with larger sample sizes, more time points, and longer follow-up times are necessary to confirm this association.Copyright © 2018 Elsevier Inc. All rights reserved.

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