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Expert Rev Clin Pharmacol · Jan 2015
ReviewDabrafenib in combination with trametinib for the treatment of metastatic melanoma.
- Mark M Awad and Ryan J Sullivan.
- Massachusetts General Hospital Cancer Center, Boston, Massachusetts, USA.
- Expert Rev Clin Pharmacol. 2015 Jan 1; 8 (1): 25-33.
AbstractOncogenic BRAF mutations are present in approximately 40-50% of patients with metastatic melanoma. Targeting BRAF mutations with either small molecule inhibitors of BRAF or one of the downstream mediators of oncogenic BRAF - MEK - is associated with improved outcomes compared with chemotherapy and has led to the US FDA approval of two BRAF inhibitors - vemurafenib and dabrafenib - and the MEK inhibitor trametinib. Further, the combination of dabrafenib and trametinib is well tolerated and associated with higher responses and improved survival compared with single-agent BRAF inhibitors.
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