• J. Cardiothorac. Vasc. Anesth. · Apr 2019

    Review

    Levosimendan in Cardiac Surgery: Evaluating the Evidence.

    • Shaji A Faisal, David A Apatov, Harish Ramakrishna, and Menachem M Weiner.
    • Department of Anesthesiology, Icahn School of Medicine at Mount Sinai, New York, NY.
    • J. Cardiothorac. Vasc. Anesth. 2019 Apr 1; 33 (4): 1146-1158.

    AbstractLevosimendan, a calcium-sensitizing and Adenosine triphosphate-sensitive potassium channel opening inodilator, has the potential to improve cardiac function without increasing oxygen consumption. The evidence supporting the use of levosimendan in the cardiac surgical perioperative period is not well-established. Recently, large-scale randomized controlled trials studying the utility of levosimendan in cardiac surgery have been conducted. This review examines the physiological and pharmacologic properties of levosimendan and evaluates the literature regarding the use of levosimendan in patients undergoing cardiac surgery.Copyright © 2018 Elsevier Inc. All rights reserved.

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