• Anshit Goyal, Iahn Cajigas, George M Ibrahim, Carole D Brathwaite, Ziad Khatib, Toba Niazi, Sanjiv Bhatia, and John Ragheb.
• Mayo Clinic Neuro-Informatics Laboratory, Mayo Clinic, Rochester, Minnesota, USA.
• World Neurosurg. 2018 Oct 1; 118: 42-46.

BackgroundMedulloblastomas are common childhood central nervous system tumors that are prone to leptomeningeal spread. Intramedullary dissemination is rare with very few case reports existing in the available literature.Case DescriptionThe authors here present a case of a 14-year-old boy with Li-Fraumeni syndrome and medulloblastoma who underwent surgical resection of spinal intramedullary spread. Histopathology revealed the tumor to be anaplastic medulloblastoma, same as the intracranial lesions. Genetic testing of the metastatic deposit revealed loss of functions mutations in SUFU, NOTCH3, and TP53 and TERC amplification. An improvement in ambulatory function at short-term follow-up was noted before the patient died of disseminated disease.ConclusionsIntramedullary metastasis of medulloblastoma remains a rare disease. Surgical resection might play a possible role in management in addition to radiation and chemotherapy.Copyright © 2018 Elsevier Inc. All rights reserved.

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