• J. Pediatr. Hematol. Oncol. · May 2013

    Case Reports

    Successful treatment of refractory immune thrombocytopenia with rituximab in a 10-week-old infant.

    • Charmaine Gray, Kongolo Kalumba, Nalini Pati, Anna Peterson, and Tom G Connell.
    • Departments of General Medicine, Murdoch Children's Research Institute, Royal Children's Hospital Melbourne, Parkville, VIC, Australia.
    • J. Pediatr. Hematol. Oncol. 2013 May 1; 35 (4): e174-7.

    AbstractImmune thrombocytopenic purpura (ITP) that is unresponsive to conventional treatment is uncommon. In this situation, additional therapeutic options are limited and management is challenging. We describe the case of a 10-week-old infant that developed life-threatening ITP that was unresponsive to immunoglobulin and corticosteroids that was successfully managed with the monoclonal antibody rituximab. The literature on the use of rituximab in nonresponsive ITP is reviewed.

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