• J. Cutan. Pathol. · Apr 2014

    Review Case Reports

    Nodular secondary syphilis with associated granulomatous inflammation: case report and literature review.

    • Carolyn Rysgaard, Erik Alexander, and Brian L Swick.
    • Department of Pathology, University of Iowa, Iowa City, IA, USA.
    • J. Cutan. Pathol. 2014 Apr 1; 41 (4): 370-9.

    AbstractA 62-year-old male presented with a 10-day history of a diffuse, erythematous papular rash sparing the palms and soles. Histopathologic examination of a skin lesion showed loose non-caseating granulomas in a lymphoplasmacytic background. Scattered spirochetes were identified by Treponema pallidum immunohistochemistry, in keeping with a diagnosis of secondary syphilis. Granulomatous inflammation in secondary syphilis is uncommon. A review of the literature reveals that the majority of prior reported cases of granulomatous secondary syphilis share similar characteristics to this case; namely, a papular or nodular clinical presentation, sparing of the palms and soles, and collections of epithelioid histiocytes with associated lymphocytes and variable numbers of plasma cells. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

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