• Joost L M Jongen, Guy Hans, Honorio T Benzon, Frank Huygen, and Craig T Hartrick.
• Department of Neurology, Erasmus MC, Rotterdam, The Netherlands; Department of Anesthesiology, Erasmus MC, Rotterdam, The Netherlands.
• Pain Pract. 2014 Mar 1;14(3):283-95.

AbstractNeuropathic pain is a serious chronic condition strongly affecting quality of life, which can be relieved but cannot be cured. Apart from symptomatic management, treatment should focus on the underlying disorder. The estimated prevalence is at least 1% to 5% of the general population. Neuropathic pain is characterized both by spontaneous and evoked pain. A diagnosis of neuropathic pain can usually be established based solely on history and neurological examination. Ancillary investigations may include EMG and computerized tomography/magnetic resonance imaging scans, depending on the localization of the suspected lesion. A limited number of agents, primarily directed at symptom control, are currently approved for use in neuropathic pain. A mechanism-based approach to pharmacological intervention supports the use of polypharmacy in neuropathic pain.© 2013 World Institute of Pain.

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