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Review Meta Analysis
Rolapitant: a pooled analysis of its efficacy and safety in the prophylaxis of chemotherapy-induced nausea and vomiting.
- Omar Abdel-Rahman and Mona Fouad.
- Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
- Future Oncol. 2016 Mar 1; 12 (6): 871-9.
BackgroundWe conducted a pooled analysis of rolapitant-containing regimens versus control in the prophylaxis of chemotherapy-induced nausea and vomiting.MethodologyEligible studies included randomized studies evaluating rolapitant-containing regimens in the settings of highly emetogenic and moderately emetogenic chemotherapy.ResultsThe pooled relative risk for complete response in the overall phase was 1.23 (95% CI: 1.18-1.33; p < 0.00001), the pooled relative risk for no significant nausea in the overall phase was 1.17 (95% CI: 1.04-1.32; p = 0.008) and the pooled RR for no emesis in the overall phase was 1.24 (95% CI: 1.18-1.31; p < 0.00001).ConclusionRolapitant-based regimens are associated with higher rates of complete response, no significant nausea and no emesis with highly/moderately emetogenic chemotherapy compared with control regimens.
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