• Internal medicine · Jan 2017

    Case Reports

    A Suspected Case of an Alveolar Haemorrhage Caused by Dasatinib.

    • Yoritake Sakoda, Yojiro Arimori, Masakatsu Ueno, and Takafumi Matsumoto.
    • Department of Respiratory Medicine, St. Mary's Hospital, Japan.
    • Intern. Med. 2017 Jan 1; 56 (2): 203-206.

    AbstractA 39-year-old man treated with dasatinib for chronic myelogenous leukaemia presented to our hospital with haemoptysis, coughing, and dyspnoea. Chest radiography and computed tomography revealed ground-glass opacities and a crazy-paving pattern. Bronchoalveolar lavage was not performed due to serious hypoxemia and bleeding. Significant bleeding from the peripheral bronchi led to a diagnosis of an alveolar haemorrhage. Dasatinib-induced alveolar haemorrhaging was suspected based on the clinical findings. His condition improved immediately after dasatinib withdrawal and initiation of steroid therapy. Reports of alveolar haemorrhaging induced by dasatinib are rare. As such, this is considered an important case.

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