• Expert Rev Hematol · Aug 2015

    Review

    Brentuximab vedotin for the treatment of Hodgkin's lymphoma.

    • Anh Pham and Robert Chen.
    • Department of Hematology and Hematopoietic Cell Transplantation, City of Hope Cancer Center, 1500 E Duarte Rd, Duarte, CA 91010, USA.
    • Expert Rev Hematol. 2015 Aug 1; 8 (4): 403-12.

    AbstractAlthough Hodgkin's lymphoma is considered a highly curable cancer, a substantial portion of patients will be refractory or will relapse after first-line therapies and even after subsequent autologous stem cell transplantation. With the absence of effective salvage therapies, these patients carry a poor prognosis with dismal survival. In this therapeutic void, the antibody-drug conjugate brentuximab vedotin was introduced and has since yielded impressive and durable response with minimal and reversible toxicity. Such efficacy in the relapse-refractory setting has led to new hypotheses and dramatic changes in our treatment strategies of Hodgkin's lymphoma. Numerous clinical trials evaluating brentuximab in the frontline and various other treatment settings are forthcoming and will demonstrate the full extent of the drug's impact.

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