• Zhiji Tang, Qianliang Huang, Jinshi Zhang, Ruijin Yang, Wenjin Wei, and Hongyi Liu.
• Department of Neurosurgery, the Affiliated Brain Hospital, Nanjing Medical University, Nanjing, People's Republic of China; Department of Neurosurgery, Ganzhou People's Hospital, Ganzhou, People's Republic of China.
• World Neurosurg. 2018 Nov 1; 119: e389-e394.

ObjectiveThe purpose of this study was to analyze the risk factors for 14-day mortality in pediatric patients undergoing early decompressive craniectomy (DC) after traumatic brain injury (TBI).MethodsThis retrospective analysis included all pediatric patients (≤16 years of age) undergoing DC within 12 hours of TBI between August 2011 and July 2017 at the authors' institute. Demographic information, clinical characteristics, surgical information, and laboratory parameters were retrieved from medical records. Risk factors for 14-day mortality were analyzed using multivariate logistic regression models. First, potentially relevant variables were compared between those who died within 14 days versus those who did not. Variables with P < 0.10 were entered into the final multivariate regression analysis.ResultsA total of 36 patients (23 boys and 13 girls; median age, 7 years) were included in the analysis. Fall (n = 19, 52.8%) was the leading cause of injury. The 14-day mortality was 38.9% (14/36). At the time of admission, the median Glasgow Score Scale (GCS) was 6 (IQR 4-8), and the mean Injury Severity Score (ISS) (± standard deviation) was 29.03 ± 8.54. Preoperative hypoxia, defined as oxyhemoglobin arterial saturation <90% or apnea >20 seconds, was observed in 6 patients (16.7%). Coagulopathy was present in 14 patients (38.9%). Multivariate logistic regression analysis suggested an association between 14-day mortality and younger age (odds ratio [OR] = 0.708, 95% confidence interval [CI]: 0.513-0.978; P = 0.036) and higher ISS (OR = 1.399; 95% CI: 1.023-1.914; P = 0.035).ConclusionsIn children undergoing early DC after TBI, risk factors for 14-day mortality include younger age and higher ISS.Copyright © 2018 Elsevier Inc. All rights reserved.

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