• Sci China Life Sci · Apr 2016

    Review

    Treatment of solid tumors with chimeric antigen receptor-engineered T cells: current status and future prospects.

    • Shengmeng Di and Zonghai Li.
    • State Key Laboratory of Oncogenes & Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200032, China.
    • Sci China Life Sci. 2016 Apr 1; 59 (4): 360-9.

    AbstractChimeric antigen receptors (CARs) are artificial recombinant receptors that generally combine the antigen-recognition domain of a monoclonal antibody with T cell activation domains. Recent years have seen great success in clinical trials employing CD19-specific CAR-T cell therapy for B cell leukemia. Nevertheless, solid tumors remain a major challenge for CAR-T cell therapy. This review summarizes the preclinical and clinical studies on the treatment of solid tumors with CAR-T cells. The major hurdles for the success of CAR-T and the novel strategies to address these hurdles have also been described and discussed.

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