• Alana M Flexman, Raphaële Charest-Morin, Liam Stobart, John Street, and Christopher J Ryerson.
• Department of Anesthesiology, Pharmacology and Therapeutics, Vancouver General Hospital, University of British Columbia, Room 2449 JPP 899 West 12th Avenue, Vancouver, BC, Canada, V5Z 1M9. Electronic address: alana.flexman@vch.ca.
• Spine J. 2016 Nov 1; 16 (11): 1315-1323.

Background ContextFrailty is defined as a state of decreased reserve and susceptibility to stressors. The relationship between frailty and postoperative outcomes after degenerative spine surgery has not been studied.PurposeThis study aimed to (1) determine prevalence of frailty in the degenerative spine population; (2) describe patient characteristics associated with frailty; and (3) determine the association between frailty and postoperative complications, mortality, length of stay, and discharge disposition.Study DesignThis is a retrospective analysis on a prospectively collected cohort from the National Surgical Quality Improvement Program (NSQIP).Patient SampleA total of 53,080 patients who underwent degenerative spine surgery between 2006 and 2012 were included in the study.Outcome MeasuresA modified frailty index (mFI) with 11 variables derived from the NSQIP dataset was used to determine prevalence of frailty and its correlation with a composite outcome of perioperative complications as well as hospital length of stay, mortality, and discharge disposition.MethodsAfter calculating the mFI for each patient, the prevalence and predictors of frailty were determined for our cohort. The association of frailty with postoperative outcomes was determined after adjusting for known and suspected confounders using multivariate logistic regression.ResultsFrailty was present in 2,041 patients within the total population (4%) and in 8% of patients older than 65 years. Frailty severity increased with increasing age, male sex, African American race, higher body mass index, recent weight loss, paraplegia or quadriplegia, American Society of Anesthesiologists (ASA) score, and preadmission residence in a care facility. Frailty severity was an independent predictor of major complication (OR 1.15 for every 0.10 increase in mFI, 95%CI 1.09-1.21, p<.0005) and specifically predicted reoperation for postsurgical infection (OR 1.3, 95%CI 1.16-1.46, p<.0005). Prolonged length of stay and discharge to a new facility were also independently predicted by frailty severity (p<.0005). Frailty severity predicted 30-day mortality on unadjusted (OR 2.05, 95%CI 1.70-2.48, p<.0005) and adjusted analyses (OR 1.48, 95%CI 1.18-1.86, p<.0005).ConclusionsFrailty is an important predictor of postoperative outcomes following degenerative spine surgery. Preoperative recognition of frailty may be useful for perioperative optimization, risk stratification, and patient counseling.Copyright © 2016 Elsevier Inc. All rights reserved.

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