• Antiviral research · Jan 2016

    Teicoplanin inhibits Ebola pseudovirus infection in cell culture.

    • Yizhuo Wang, Rui Cui, Guiming Li, Qianqian Gao, Shilin Yuan, Ralf Altmeyer, and Gang Zou.
    • Unit of Anti-infective Research, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.
    • Antiviral Res. 2016 Jan 1; 125: 1-7.

    AbstractThere is currently no approved antiviral therapy for treatment of Ebola virus disease. To discover readily available approved drugs that can be rapidly repurposed for treatment of Ebola virus infections, we screened 1280 FDA-approved drugs and identified glycopeptide antibiotic teicoplanin inhibiting Ebola pseudovirus infection by blocking virus entry in the low micromolar range. Teicoplanin could be evaluated further and incorporated into ongoing clinical studies. Copyright © 2015 Elsevier B.V. All rights reserved.

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