• World Neurosurg · Nov 2018

    Case Reports

    Successful Novel Treatment of a High-Grade Paraspinal Primitive Neuroectodermal Tumor: A 3-Year Follow-Up After Surgery, Intensity-Modulated Radiation Therapy and Oral Temozolomide.

    • Tarek Y El Ahmadieh, Jack M Raisanen, James Botros, Jean-Luc Kabangu, Edward Pan, and Wayne Gluf.
    • Department of Neurological Surgery, Zale Lipshy Hospital, The University of Texas Southwestern, Dallas, Texas, USA. Electronic address: tarek.elahmadieh@phhs.org.
    • World Neurosurg. 2018 Nov 1; 119: 340-344.

    BackgroundParaspinal masses are a relatively uncommon but diverse group of lesions that can be neoplastic or non-neoplastic. Peripheral primitive neuroectodermal tumors of the lumbar paraspinal region with diffuse and strong glial differentiation have never been reported before.Case DescriptionWe report a primary paraspinal primitive neuroectodermal tumor with overwhelming glial differentiation in a 23-year-old female patient who presented with intractable right lower extremity pain. The patient underwent a 2-staged operation with gross total resection of the mass followed by intensity-modulated radiation therapy and oral temozolomide, a regimen employed for high-grade intracranial gliomas. Serial imaging revealed no evidence of recurrence after 3 years.ConclusionsAlthough these lesions appear to be exceptionally rare, an approach similar to that of intracranial high-grade glial tumors was effective in our experience. Our patient had no evidence of recurrence at 3-year follow-up.Copyright © 2018 Elsevier Inc. All rights reserved.

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