• Moritoki Egi, Jun Kataoka, Takashi Ito, Osamu Nishida, Hideto Yasuda, Hiroshi Okamaoto, Akira Shimoyama, Masayo Izawa, Shinsaku Matsumoto, Nana Furushima, Shigeki Yamashita, Koji Takada, Masahide Ohtsuka, Noritomo Fujisaki, Nobuaki Shime, Nobuhiro Inagaki, Yasuhiko Taira, Tomoaki Yatabe, Kenichi Nitta, Takeshi Yokoyama, Shigeki Kushimoto, Kentaro Tokunaga, Matsuyuki Doi, Takahiro Masuda, Yasuo Miki, Kenichi Matsuda, Takehiko Asaga, Keita Hazama, Hiroki Matsuyama, Masaji Nishimura, Satoshi Mizobuchi, and ; ABOVE investigators.
• Department of Anesthesiology, Kobe University Hospital, Hyogo, Japan. Electronic address: moriori@tg8.so-net.ne.jp.
• J Crit Care. 2018 Aug 1; 46: 1-5.

PurposeTo observe arterial oxygen in relation to fraction of inspired oxygen (FIO2) during mechanical ventilation (MV).Materials And MethodsIn this multicenter prospective observational study, we included adult patients required MV for >48h during the period from March to May 2015. We obtained FIO2, PaO2 and SaO2 from commencement of MV until the 7th day of MV in the ICU.ResultsWe included 454 patients from 28 ICUs in this study. The median APACHE II score was 22. Median values of FIO2, PaO2 and SaO2 were 0.40, 96mmHg and 98%. After day two, patients spent most of their time with a FIO2 between 0.3 and 0.49 with median PaO2 of approximately 90mmHg and SaO2 of 97%. PaO2 was ≥100mmHg during 47.2% of the study period and was ≥130mmHg during 18.4% of the study period. FIO2 was more likely decreased when PaO2 was ≥130mmHg or SaO2 was ≥99% with a FIO2 of 0.5 or greater. When FIO2 was <0.5, however, FIO2 was less likely decreased regardless of the value of PaO2 and SaO2.ConclusionsIn our multicenter prospective study, we found that hyperoxemia was common and that hyperoxemia was not corrected.Copyright © 2018 Elsevier Inc. All rights reserved.

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