• American heart journal · Jun 1993

    Review

    Deep hypothermic circulatory arrest during cardiac surgery: effects on cerebral blood flow and cerebral oxygenation in children.

    • C K Phoon.
    • Department of Pediatrics, Johns Hopkins Hospital, Baltimore, Md.
    • Am. Heart J. 1993 Jun 1; 125 (6): 1739-48.

    AbstractDeep hypothermic circulatory arrest has become an essential technique to allow repair of complex congenital cardiac lesions in children. The arrested state has concerned the surgeon, cardiologist, and anesthesiologist alike, and yet deep hypothermic circulatory arrest has been highly successful with a low incidence of neurologic sequelae. Studies of cerebral blood flow and cerebral oxygenation demonstrate that the arrest hypothermic brain does not develop the immediate postarrest hyperemia or hyperoxia seen in normothermic ischemic brain models. However, both hypothermic and normothermic ischemic brains exhibit hypoperfusion beyond the immediate recirculation period, likely coupled with a reduced cerebral metabolic rate. That the hypothermic arrested brain likely becomes anoxic and recovery of the anoxic brain depends in large part on recirculatory hemodynamics suggests that the lack of hyperemia and hyperoxia may play more major roles than was previously believed. The mechanism of protection may be related to suppression of oxygen free radicals.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…