• Xiuli Zhang and Piyush K Sharma.
• Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, United States.
• Vaccine. 2017 Feb 15; 35 (7): 1094-1100.

AbstractThe development of next generation sequencing technologies has revolutionized our understanding of how specific genetic events contribute to cancer initiation and progression. Dramatic improvements in instrument design and efficiency, combined with significant cost reductions has permitted a systematic analysis of the mutational landscape in a variety of cancer types. At the same time, a detailed map of the cancer mutanome in individual cancers offers a unique opportunity to develop personalized cancer vaccine strategies targeting neoantigens. Recent studies in both preclinical models and human cancer patients demonstrate that neoantigens (1) are important targets following checkpoint inhibition therapy, (2) have been identified as the target of adoptive T cell therapies, and (3) can be successfully targeted with personalized vaccines. Taken together, these observations provide strong rationale for the clinical translation of personalized cancer vaccines.Copyright © 2016 Elsevier Ltd. All rights reserved.

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