• Semin. Thorac. Cardiovasc. Surg. · Jan 2009

    Review

    Multimodality strategies in malignant pleural mesothelioma.

    • Walter Weder, Isabelle Opitz, and Rolf Stahel.
    • Division of Thoracic Surgery, University Hospital Zurich, Zürich, Switzerland. walter.weder@chi.usz.ch
    • Semin. Thorac. Cardiovasc. Surg. 2009 Jan 1; 21 (2): 172-6.

    AbstractOver the last decade, several improvements have been made in the diagnosis and treatment of malignant pleural mesothelioma, including better understanding of tumor biology, availability of more potent chemotherapeutic drugs, improved surgical management, and optimized multidisciplinary therapy. Radical tumor resection by means of extrapleural pneumonectomy (EPP) is now feasible with acceptable morbidity and mortality, even after neoadjuvant chemotherapy, if performed in specialized centers. To date, the best survival data have been reported after multimodality treatment strategies that include surgical resection. In this article, we discuss several strategies that involve EPP or pleurectomy/decortication in combination with various adjuvant and neoadjuvant therapies.

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