• Expert Rev Hematol · Jun 2016

    Review

    Immunotherapy approaches to treat adult acute lymphoblastic leukemia.

    • Elena Maino, Massimiliano Bonifacio, Anna Maria Scattolin, and Renato Bassan.
    • a UOC Ematologia , Ospedale dell'Angelo & Ospedale SS. Giovanni e Paolo , Mestre - Venezia , Italy.
    • Expert Rev Hematol. 2016 Jun 1; 9 (6): 563-77.

    AbstractRecent developments in immunotherapy are improving treatment results of B-precursor acute lymphoblastic leukemia. This advancement is promoted by new monoclonal antibodies such as inotuzumab ozogamicin, ofatumumab and blinatumomab, by rituximab, and by genetically engineered chimeric antigen receptor-modified T-cells. These treatments, variously targeting CD22, CD20 and CD19 antigens, yield unprecedented high rates of hematologic and molecular remissions even when used in monotherapy and in chemo-resistant or post-transplantation relapsed patients. Beside the encouraging results in relapsed/refractory disease, these agents may open a totally new era in the frontline management of this illness, redefining treatment standards and options for different risk subsets and placing the achievement of a molecular remission at the forefront of treatment objectives. The ever increasing importance of modern immunotherapy in improving treatment design and therapeutic outcome is reviewed.

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