• Acta Anaesthesiol Belg · Jan 1987

    Comparative Study

    Atropine methylbromide and glycopyrrolate. A comparative study during reversal of neuromuscular block.

    • B Dworacek, J Rupreht, A Bode, and M J Walhout.
    • Academic Hospital Dijkzigt, Rotterdam, The Netherlands.
    • Acta Anaesthesiol Belg. 1987 Jan 1; 38 (2): 147-52.

    AbstractTwo quaternary anticholinergics, atropine methylbromide (methylatropine bromide, MAB) and glycopyrrolate (ROBINUL) were compared as adjuncts to neostigmine for the reversal of residual nondepolarising neuromuscular block. MAB 0.75 mg in combination with neostigmine 2 mg produced a marked initial rise in heart rate. This was significantly greater than that produced by the administration of glycopyrrolate 0.4 mg with neostigmine. The antisialogogue effects of the two anticholinergics were identical and the central nervous system status of the patients was similar. It is concluded that, with the doses used in this study, glycopyrrolate is a superior alternative to MAB and is the drug of choice if a quaternary ammonium anticholinergic is required.

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