• Psychiatry research · Feb 1988

    Randomized Controlled Trial Clinical Trial

    Effects of laboratory-induced panic-anxiety on subsequent provocative infusions.

    • V K Yeragani, R Balon, J M Rainey, A Ortiz, R Berchou, H Lycaki, and R Pohl.
    • Outpatient Department, Lafayette Clinic, Detroit, MI 48207.
    • Psychiatry Res. 1988 Feb 1; 23 (2): 161-6.

    AbstractThe effects of infusion-induced panic-anxiety on subsequent pre-infusion anxiety ratings and infusion-induced panic attacks were studied in 64 panic disorder patients, in a double-blind randomized study using sodium lactate, isoproterenol, and placebo infusions. While there was a decrease of preinfusion anxiety from one infusion to the next infusion both for panickers and nonpanickers, there was no evidence of either a significant decrease or an increase in the frequency of subsequent panic attacks. These results suggest that there is neither a desensitizing nor a sensitizing effect of pharmacologically induced panic attacks on subsequent infusions in a serial three-infusion design.

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