• World Neurosurg · Nov 2018

    Case Reports

    Widely Metastatic Choroid Plexus Carcinoma Associated with Novel TP53 Somatic Mutation.

    • Brandon S Baksh, Namita Sinha, Afshin Salehi, Rowland H Han, Brandon A Miller, Sonika Dahiya, Karen M Gauvain, and David D Limbrick.
    • Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri, USA. Electronic address: brandonbaksh@wustl.edu.
    • World Neurosurg. 2018 Nov 1; 119: 233-236.

    BackgroundChoroid plexus carcinoma (CPC) is a rare, malignant tumor occurring more commonly in children than adults. This case report describes the clinical course of a 3-year-old boy with a rare case of metastatic CPC with a novel TP53 mutation.Case DescriptionA 3-year-old boy presented with postconcussive symptoms after a fall. Computed tomography and magnetic resonance imaging revealed lesions in the suprasellar cistern, left lateral ventricle, and cauda equina. The tumor was diagnosed as choroid plexus carcinoma with a novel TP53 V216M somatic mutation. The patient underwent resection of the left lateral ventricle lesion.ConclusionWe describe a case of CPC with highly metastatic characteristics and a novel TP53 mutation. Our report implicates TP53 in the pathogenesis of pediatric CPC, and we emphasize that CPC in children should prompt careful consideration of TP53 status to inform prognosis and clinical treatment.Copyright © 2018 Elsevier Inc. All rights reserved.

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