• Ainara Campino, Elena Santesteban, Pilar Pascual, Beatriz Sordo, Casilda Arranz, Maria Unceta, and Ion Lopez-de-Heredia.
• Hospital Pharmacy, Cruces University Hospital, Plaza de Cruces s/n, 48903, Barakaldo, Bizkaia, Spain. ainara.campinovillegas@osakidetza.eus.
• Eur. J. Pediatr. 2016 Jun 1; 175 (6): 755-65.

UnlabelledThis study assessed the rate of errors in intravenous medicine preparation at bedside in neonatal intensive care units versus preparation error rate in a hospital pharmacy service before and after several strategies were implemented. We performed a prospective observational study during 2013-2015. Ten Spanish neonatal intensive care units and one hospital pharmacy service participated in the study. Two types of preparation errors were considered, calculation errors and accuracy errors. The study was carried out over three consecutive phases: (1) pre-intervention phase, when medicine preparation samples were collected from neonatal intensive care units and hospital pharmacy service according to their normal clinical practice; (2) intervention phase, when protocol standardisation and educational strategy took place; and (3) post-intervention phase, when new medicine samples were collected after strategy implementation. In neonatal intensive care units, 1.35 % of samples registered calculation errors in pre-intervention phase; no calculation errors were registered in hospital pharmacy service samples. In post-intervention phase, no calculation errors were registered in either group. Accuracy error rate decreased both in neonatal intensive care units (54.7 vs 23 %) and hospital pharmacy service (38.3 vs 14.6 %).ConclusionCalculation errors can disappear with good standardisation protocols. Decrease in accuracy error depends on good preparation technique and environmental factors.What Is Known• Medication use is associated with a risk of errors and adverse events. Medication errors are more frequent and have more severe consequences in paediatric patients. • Lack of commercial drug formulations adapted to newborn infants makes medicine preparation process more prone to error. What is New: • Calculation errors are minimising using concentration standard protocols. Preparation rules are essential to ensure the accuracy process. • Environmental conditions affect the accuracy process.

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