• Int J Mol Sci · Jan 2018

    Review

    Incorporation of Immune Checkpoint Blockade into Chimeric Antigen Receptor T Cells (CAR-Ts): Combination or Built-In CAR-T.

    • Dok Hyun Yoon, Mark J Osborn, Jakub Tolar, and Chong Jai Kim.
    • Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea. dhyoon@amc.seoul.kr.
    • Int J Mol Sci. 2018 Jan 24; 19 (2).

    AbstractChimeric antigen receptor (CAR) T cell therapy represents the first U.S. Food and Drug Administration approved gene therapy and these engineered cells function with unprecedented efficacy in the treatment of refractory CD19 positive hematologic malignancies. CAR translation to solid tumors is also being actively investigated; however, efficacy to date has been variable due to tumor-evolved mechanisms that inhibit local immune cell activity. To bolster the potency of CAR-T cells, modulation of the immunosuppressive tumor microenvironment with immune-checkpoint blockade is a promising strategy. The impact of this approach on hematological malignancies is in its infancy, and in this review we discuss CAR-T cells and their synergy with immune-checkpoint blockade.

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