• Current diabetes reports · Jun 2006

    Review

    Development of type 2 diabetes in children and adolescents.

    • Ram Weiss, Sara E Taksali, and Sonia Caprio.
    • Curr. Diab. Rep. 2006 Jun 1; 6 (3): 182-7.

    AbstractType 2 diabetes is emerging as a significant health problem in children and adolescents. The disease usually develops in obese insulin-resistant youth with a typical pattern of lipid partitioning characterized by increased lipid deposition in myocytes, the visceral compartment, and the liver. Unfavorable adipocytokine profiles, together with a state of low-grade inflammation, create an additional metabolic burden tightly coupled to other components of the metabolic syndrome. Insufficient beta-cell compensation promotes altered glucose metabolism.

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