• Todd M Manini, James E Everhart, Kushang V Patel, Dale A Schoeller, Steve Cummings, Dawn C Mackey, Douglas C Bauer, Eleanor M Simonsick, Lisa H Colbert, Marjolein Visser, Frances Tylavsky, Anne B Newman, Tamara B Harris, and Health, Aging and Body Composition Study.
• Department of Aging and Geriatric Research, University of Florida, Gainesville, Florida, USA. tmanini@aging.ufl.edu
• Am. J. Epidemiol. 2009 Jun 15; 169 (12): 1507-16.

AbstractIn this study, the authors aimed to determine whether higher activity energy expenditure, assessed by using doubly labeled water, was associated with a reduced decline in mobility limitation among 248 older community-dwelling US adults aged 70-82 years enrolled in 1998-1999. Activity energy expenditure was calculated as total energy expenditure (assessed over 2 weeks by using doubly labeled water) minus resting metabolic rate (measured with indirect calorimetry), with adjustment for the thermic effect of food. Across sex-specific tertiles of activity energy expenditure, men in the lowest activity group experienced twice the rate of mobility limitation as men in the highest activity group (41% (n = 18) vs. 18% (n = 8)). Conversely, women in the lowest and highest activity groups exhibited similarly high rates of mobility limitation (40% (n = 16) vs. 38% (n = 15)). After adjustment for potential confounders, men with higher activity energy expenditure levels continued to show reduced risk of mobility limitation (per standard deviation (284 kcal/day): hazard ratio = 0.61, 95% confidence interval: 0.41, 0.92). Women showed no association (per standard deviation (226 kcal/day): hazard ratio = 1.34, 95% confidence interval: 0.98, 1.85). Greater energy expenditure from any and all physical activity was significantly associated with reduced risk of developing mobility limitation among men, but not among women.

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