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J Pain Symptom Manage · May 2004
Randomized Controlled Trial Comparative Study Clinical TrialValdecoxib versus rofecoxib in acute postsurgical pain: results of a randomized controlled trial.
- Kyle S Christensen and Gail D Cawkwell.
- Wasatch Oral Surgery, West Jordan, Salt Lake City, Utah, USA.
- J Pain Symptom Manage. 2004 May 1; 27 (5): 460-70.
AbstractThe analgesic efficacy of the cyclooxygenase-2 specific inhibitors, valdecoxib and rofecoxib, were evaluated in patients following oral surgery. In a randomized, double-blind, controlled trial, patients experiencing moderate or severe pain received single-dose valdecoxib 40 mg (n=99), rofecoxib 50 mg (n=101), or placebo (n=50) within 4 hours after multiple third molar extraction with bone removal. Onset of action was significantly faster with valdecoxib 40 mg (30 minutes) compared with rofecoxib 50 mg (45 minutes), as measured by pain intensity difference and pain relief scores (P
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