• Jaap Jan Vos, Cornelis H Willems, Kai van Amsterdam, Johannes P van den Berg, Rob Spanjersberg, Struys Michel M R F MMRF From the Department of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. , and Scheeren Thomas W L TWL From the Department of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands..
• From the Department of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
• Anesth. Analg. 2019 Aug 1; 129 (2): 409-415.

BackgroundPulse oximetry-derived oxygen saturation is typically >97% in normoxia and hyperoxia, limiting its clinical use. The new Oxygen Reserve Index (ORi), a relative indicator of the partial pressure of oxygen dissolved in arterial blood (PaO2) in the range of 100-200 mm Hg, may allow additional monitoring of oxygen status.MethodsIn this prospective validation intervention study, 20 healthy volunteers were breathing standardized oxygen concentrations ranging from mild hypoxia (fraction of inspired oxygen = 0.14) to hyperoxia (fraction of inspired oxygen = 1.0) via a tight-fitting face mask. ORi was measured noninvasively by multiwavelength pulse co-oximetry using 2 finger sensors. These ORi values (unitless scale, 0.00-1.00) were compared with measured PaO2 values. Repeated-measurements correlation analysis was performed to assess the ORi/PaO2 relationship. ORi trending ability was assessed using a 4-quadrant plot. The area under the receiver operating characteristics curve was calculated to assess the prediction of hypoxia (low-ranged PaO2, <100 mm Hg).ResultsWithin the ORi-sensitive range, a strong positive correlation was found between ORi and PaO2 for both sensors (R = 0.78 and 0.83; P < .0001). ORi trending of PaO2 was good within this range (concordance rate = 94%). The prediction of PaO2 <100 mm Hg was also good, with an area under the receiver operating characteristics curve of 0.91 and 99% sensitivity and 82% specificity.ConclusionsIn this prospective volunteer validation study, a strong and positive correlation between PaO2 and ORi was found, together with a good trending ability. Based on these data, the future use of ORi as a continuous noninvasive monitoring tool for assessing oxygenation status in patients receiving supplemental oxygen might be supported.

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