• Veterinary microbiology · Dec 2015

    Live poultry market workers are susceptible to both avian and swine influenza viruses, Guangdong Province, China.

    • Jidang Chen, Jun Ma, Sarah K White, Zhenpeng Cao, Yun Zhen, Shuyi He, Wanjun Zhu, Changwen Ke, Yongbiao Zhang, Shuo Su, and Guihong Zhang.
    • College of Veterinary and National Engineering Research Center for Breeing Swine Industry/South China Agricultural University, Guangzhou, Guangdong Province, PR China; National and Regional Joint Engineering Laboratory for Medicament of Zoonosis Prevention and Control, Guangzhou, Guangdong Province, PR China; Key Laboratory of Animal Vaccine Development, Ministry of Agriculture, Guangzhou, Guangdong Province, PR China; Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, Guangdong Center for Disease Control and Prevention, Guangzhou, Guangdong Province, PR China.
    • Vet. Microbiol. 2015 Dec 31; 181 (3-4): 230-5.

    AbstractGuangdong Province is recognized for dense populations of humans, pigs, poultry and pets. In order to evaluate the threat of viral infection faced by those working with animals, a cross-sectional, sero-epidemiological study was conducted in Guangdong between December 2013 and January 2014. Individuals working with swine, at poultry farms, or live poultry markets (LPM), and veterinarians, and controls not exposed to animals were enrolled in this study and 11 (4 human, 3 swine, 3 avian, and 1 canine) influenza A viruses were used in hemagglutination inhibition (HI) assays (7 strains) and the cross-reactivity test (9 strains) in which 5 strains were used in both tests. Univariate analysis was performed to identify which variables were significantly associated with seropositivity. Odds ratios (OR) revealed that swine workers had a significantly higher risk of elevated antibodies against A/swine/Guangdong/L6/2009(H1N1), a classical swine virus, and A/swine/Guangdong/SS1/2012(H1N1), a Eurasian avian-like swine virus than non-exposed controls. Poultry farm workers were at a higher risk of infection with avian influenza H7N9 and H9N2. LPM workers were at a higher risk of infection with 3 subtypes of avian influenza, H5N1, H7N9, and H9N2. Interestingly, the OR also indicated that LPM workers were at risk of H1N1 swine influenza virus infection, perhaps due to the presence of pigs in the LPM. While partial confounding by cross-reactive antibodies against human viruses or vaccines cannot be ruled out, our data suggests that animal exposed people as are more likely to have antibodies against animal influenza viruses. Copyright © 2015 Elsevier B.V. All rights reserved.

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