• World Neurosurg · Dec 2018

    Statin Therapy and Diabetes Do Not Affect Aneurysm Occlusion or Clinical Outcomes Following Pipeline Embolization Device Treatment: a Preliminary Study.

    • Mohamed M Salem, Georgios A Maragkos, Alejandro Enriquez-Marulanda, Luis Ascanio, Krishnan Ravindran, Abdulrahman Y Alturki, Christopher S Ogilvy, Ajith J Thomas, and Justin M Moore.
    • Neurosurgical Service, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
    • World Neurosurg. 2018 Dec 1; 120: e525-e532.

    BackgroundThe effect of statins and diabetes on angiographic and clinical outcomes in aneurysms treated with pipelines has not been adequately reported. Our aim is to assess the effect of concurrent statin medications and diabetes mellitus (DM) on aneurysm occlusion status and outcomes in patients treated with the pipeline embolization device.MethodsA retrospective review of our institution's database of aneurysms treated with the pipeline embolization device between 2013 and 2017 was conducted. We collected data about statin therapy status and intensity, and identified patients with a documented history of DM. Our primary outcome was aneurysm obliteration seen on digital subtracted angiography or magnetic resonance angiography at last follow-up.ResultsWe identified 151 patients with 182 aneurysms for this cohort, with a median radiographic follow-up time of 7.2 months (6.1-14.5). Thirty-nine patients were taking statins, and 112 patients did not receive statins. Log-rank tests revealed no statistically significant difference in occlusion rates between patients with and without statin therapy (P = 0.30). A history of DM was documented in 11 patients, with 14 aneurysms in total; 140 patients with 168 aneurysms had no history of DM. Similarly, there were no differences in occlusion rates between the diabetic and nondiabetic groups in multivariate analysis (P = 0.24). Only 2 patients showed significant in-stent stenosis on angiographic follow up, and both were diabetic.ConclusionsOur analysis did not identify a statistically significant association between statin therapy or DM and higher occlusion rates or better outcomes after pipeline embolization. Diabetic patients may have a theoretic risk of significant in-stent stenosis.Copyright © 2018 Elsevier Inc. All rights reserved.

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