• Marcin Braun, Bartłomiej Tomasik, Michał Bieńkowski, Karol Wiśniewski, Dorota-Jesionek Kupnicka, Dariusz Jaskólski, Wielisław Papierz, Jacek Fijuth, and Radzislaw Kordek.
• Department of Pathology, Chair of Oncology, Medical University of Lodz, Lodz, Poland; Postgraduate School of Molecular Medicine, Medical University of Warsaw, Warsaw, Poland. Electronic address: braunmarcin@gmail.com.
• World Neurosurg. 2018 Dec 1; 120: 1-14.

BackgroundPapillary tumors of the pineal region (PTPRs) are malignant World Health Organization grade II/III tumors; however, they may perfectly mimic benign tumors (e.g., pineocytomas [World Health Organization grade I]).Case DescriptionWe present a case of a 28-year-old man with a 35-mm tumor of the pineal region. Considering the typical radiological and pathologic presentation, the tumor was first diagnosed as pineocytoma. However, despite first total resection, the tumor recurred after 7 years. The recurrent neoplasm was composed mainly of papillary structures with low-grade atypical cells positive for CKAE1/AE3 and CK18. This categorization led to the final diagnosis of PTPR. The patient underwent adjuvant radiotherapy, which vastly improved his neurologic condition and resulted in significant tumor regression.ConclusionsThis case exemplifies that PTPRs can perfectly mimic pineocytomas and simple staining for cytokeratins may warrant correct diagnosis and better treatment.Copyright © 2018 Elsevier Inc. All rights reserved.

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