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Expert Rev Anti Infect Ther · Sep 2012
ReviewReappraising the use of β-lactams to treat tuberculosis.
- Sebastian G Kurz and Robert A Bonomo.
- Division of Pulmonary, Critical Care and Sleep Medicine, University Hospitals Case Medical Center and Louis Stokes Department of Veterans Affairs Medical Center, Cleveland, OH 44106, USA.
- Expert Rev Anti Infect Ther. 2012 Sep 1; 10 (9): 999-1006.
AbstractThe emergence of multidrug-resistant and extensively drug-resistant tuberculosis calls for novel approaches to treatment. Recent studies have shown that BlaC, the β-lactamase of Mycobacterium tuberculosis, is the major determinant of β-lactam resistance. This review invites the reader to explore evidence in order to answer the questions: can β-lactam and β-lactamase inhibitors adequately treat M. tuberculosis infection and are they a viable option in the management of resistant tuberculosis today?
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