• Antimicrob. Agents Chemother. · Nov 2014

    In vitro susceptibility of Mycobacterium tuberculosis isolates to an oral carbapenem alone or in combination with β-lactamase inhibitors.

    • Yasuhiro Horita, Shinji Maeda, Yuko Kazumi, and Norio Doi.
    • Department of Pathophysiology and Host Defense, Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Matsuyama, Kiyose, Tokyo, Japan.
    • Antimicrob. Agents Chemother. 2014 Nov 1; 58 (11): 7010-4.

    AbstractWe evaluated the antituberculosis (anti-TB) activity of five β-lactams alone or in combination with β-lactamase inhibitors against 41 clinical isolates of Mycobacterium tuberculosis, including multidrug-resistant and extensively drug-resistant strains. Of those, tebipenem, an oral carbapenem, showed the most potent anti-TB activity against clinical isolates, with a MIC range of 0.125 to 8 μg/ml, which is achievable in the human blood. More importantly, in the presence of clavulanate, MIC values of tebipenem declined to 2 μg/ml or less. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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