• K Murphy, S B Haudek, M Thompson, and B P Giroir.
• Department of Pediatrics, and The Crystal Charity Ball Center for Research in Pediatric Critical Care, The University of Texas Southwestern Medical Center, Dallas 75235-9063, USA.
• New Horiz. 1998 May 1; 6 (2): 181-93.

AbstractSeptic shock is a complex pathophysiologic state which often leads to multiple organ dysfunction, multiple organ failure, and death. This review summarizes current views on the molecular biology of three aspects of septic shock: recognition of bacterial invasion and induction of the cytokine response; genetic variability among humans and their predispositions toward pathologic inflammatory responses; and the signal transduction mechanisms which account for the transfer of molecular signals from cytokine receptors on the plasma membrane to cytokine-responsive genes in the nucleus. In particular, the review summarizes the pathway involved in tumor necrosis factor signaling through nuclear factor-kappaB, and elucidates the molecular signals involved in inflammatory responses and apoptosis.

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