• Int. J. Infect. Dis. · Mar 2015

    Review

    Access to new medications for the treatment of drug-resistant tuberculosis: patient, provider and community perspectives.

    • Erica Lessem, Helen Cox, Colleen Daniels, Jennifer Furin, Lindsay McKenna, Carole D Mitnick, Thato Mosidi, Caitlin Reed, Barbara Seaworth, Jonathan Stillo, Phumeza Tisile, and Dalene von Delft.
    • Treatment Action Group, New York, NY, USA. Electronic address: erica.lessem@treatmentactiongroup.org.
    • Int. J. Infect. Dis. 2015 Mar 1; 32: 56-60.

    AbstractMultidrug-resistant tuberculosis (MDR-TB) is on the rise, and is difficult to treat. The approval of two new drugs, bedaquiline and delamanid, and growing evidence for the use of linezolid, offer renewed hope for addressing MDR-TB. However, access to these medicines remains a significant challenge. These drugs have not been registered for TB in most settings; barriers to preapproval access persist; and high pricing and intellectual property restrictions limit access. Many unanswered research questions about optimal use of these drugs also limit access, particularly for vulnerable populations. This review outlines challenges in accessing drugs encountered from the perspective of clinicians, patients and affected communities, and offers potential solutions. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

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