• Acta Anaesthesiol Scand · Aug 2012

    Randomized Controlled Trial Comparative Study

    Non-steroidal anti-inflammatory drugs reduce the stress response during sevoflurane anesthesia.

    • Z Liu, H Lu, G He, H Ma, and J Wang.
    • Department of Anesthesiology, First Affiliated Hospital of China Medical University, Shenyang, China.
    • Acta Anaesthesiol Scand. 2012 Aug 1;56(7):890-5.

    BackgroundNon-steroidal anti-inflammatory drugs are analgesics commonly used for post-operative pain. However, their effect on dosages of inhaled anesthetics during surgery is unclear. We investigated the effect of flurbiprofen axetil and parecoxib sodium on the minimum alveolar concentration of sevoflurane required to blunt stress responses to skin incision under general anesthesia.MethodsOne hundred and five adult patients were randomly allocated to four treatment groups, each receiving sevoflurane: control (sevoflurane only), lidocaine (1 mg/kg bolus, followed by continuous infusion of 20 μg/kg/min after intubation), Intravenous (IV) flurbiprofen (1 mg/kg before skin incision), and IV parecoxib (40 mg before skin incision). Following anesthetic induction and stabilization of end-tidal sevoflurane concentration, mean arterial blood pressure and heart rate were recorded 2 min before and at 5-min intervals after skin incision. The stable end-tidal sevoflurane concentration was calculated using an up-and-down method.ResultsThe minimum alveolar concentration of sevoflurane required to blunt the stress responses to skin incision in the control, lidocaine, flurbiprofen, and parecoxib groups was 4.63 ± 0.08%, 2.67 ± 0.08%, 3.33 ± 0.08%, and 3.80 ± 0.11%, respectively. These figures for the later three groups were all significantly less than that of the control group (P = 0.021, P = 0.037, and P = 0.011, respectively); that of the flurbiprofen group was significantly less than the parecoxib (P = 0.034).ConclusionThe non-steroidal anti-inflammatory drugs flurbiprofen axetil and parecoxib sodium decreased the minimum alveolar concentration of sevoflurane required to blunt the stress response to skin incision during general anesthesia.© 2012 The Authors. Acta Anaesthesiologica Scandinavica © 2012 The Acta Anaesthesiologica Scandinavica Foundation.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…