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- Fausto Salaffi, Giovanni Giacobazzi, and Marco Di Carlo.
- Rheumatology Department, Università Politecnica delle Marche, Jesi, Ancona, Italy.
- Pain Res Manag. 2018 Jan 1; 2018: 85642158564215.
AbstractChronic pain is nowadays considered not only the mainstay symptom of rheumatic diseases but also "a disease itself." Pain is a multidimensional phenomenon, and in inflammatory arthritis, it derives from multiple mechanisms, involving both synovitis (release of a great number of cytokines) and peripheral and central pain-processing mechanisms (sensitization). In the last years, the JAK-STAT pathway has been recognized as a pivotal component both in the inflammatory process and in pain amplification in the central nervous system. This paper provides a summary on pain in inflammatory arthritis, from pathogenesis to clinimetric instruments and treatment, with a focus on the JAK-STAT pathway.
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