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Journal of critical care · Aug 2018
ReviewManagement of Amanita phalloides poisoning: A literature review and update.
- Yongzhuang Ye and Zhenning Liu.
- Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China.
- J Crit Care. 2018 Aug 1; 46: 17-22.
AbstractAmanita phalloides poisoning with a high mortality is a serious health problem in the world. The typical clinical manifestations are usually characterized by the absence of any symptoms followed by severe gastrointestinal disorders and acute liver failure. Inhibition of RNA polymeraseII (RNAP II) activity, apoptosis, and oxidative stress are considered as the major mechanism of amatoxins intoxication. The current treatment measures mainly include prevention of amatoxins absorption, elimination of absorbed amatoxins, potential antidotes therapy, and liver transplantation. Nevertheless, there are no widely accepted treatment criteria for Amanita phalloides poisoning. This paper will focus on the treatment measures based on the previous studies and provide the currently available information for clinicians.Copyright © 2018 Elsevier Inc. All rights reserved.
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