• Journal of critical care · Oct 2018

    Observational Study

    Low endocan levels are predictive of Acute Respiratory Distress Syndrome in severe sepsis and septic shock.

    • Alexandre Gaudet, Erika Parmentier, Sylvain Dubucquoi, Julien Poissy, Thibault Duburcq, Philippe Lassalle, Nathalie De Freitas Caires, and Daniel Mathieu.
    • Univ. Lille, U1019 - UMR 8204 - CIIL - Center for Infection and Immunity of Lille, F-59000 Lille, France; CNRS, UMR 8204, F-59000 Lille, France; INSERM, U1019, F-59000 Lille, France; CHU Lille, Pôle de Réanimation, Hôpital Roger Salengro, F-59000 Lille, France. Electronic address: alexandre.gaudet@chru-lille.fr.
    • J Crit Care. 2018 Oct 1; 47: 121-126.

    PurposeEndocan is a circulating proteoglycan measured at high blood levels during severe sepsis, with a likely lung anti-inflammatory function. The aim of this study was to assess whether paradoxically low endocan levels at Intensive Care Unit (ICU) admission could predict Acute Respiratory Distress Syndrome (ARDS) within 72 h in severe septic patients.Materials And MethodsPatients admitted for severe sepsis in the ICU of a French University Hospital were included in a prospective single-center observational study between October 2014 and March 2016.Results72 patients admitted in ICU for severe sepsis were included. Endocan blood values at inclusion were significantly lower in patients who developed an ARDS at 72 h (p < 0.001). For endocan blood values > 5.36 ng/mL, the adjusted OR for development of ARDS at 72 h was of 0.001 (95% CI 0-0.215; p = 0.011). In our cohort, an endocan value < 2.54 ng/mL predicted ARDS at 72 h with a positive predictive value of 1 (Sp = 1 (95% CI 0.94-1)).ConclusionsIn a cohort of severe septic patients, we observed that low blood levels of endocan at ICU admission were predictive of ARDS at 72 h.Copyright © 2018 Elsevier Inc. All rights reserved.

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