• Avelino C Verceles, Chris L Wells, John D Sorkin, Michael L Terrin, Jeffrey Beans, Toye Jenkins, and Andrew P Goldberg.
• Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, United States of America. Electronic address: Avercele@som.umaryland.edu.
• J Crit Care. 2018 Oct 1; 47: 204-210.

PurposeTo compare the effects of adding a progressive multimodal rehabilitation program to usual care (MRP + UC) versus UC alone on 1) functional mobility, strength, endurance and 2) ventilator weaning and discharge status of patients with ICU-acquired weakness (ICUAW) receiving prolonged mechanical ventilation (PMV).MethodsRandomized pilot trial of an individualized MRP + UC versus UC in middle-aged and older ICU survivors with ICUAW receiving PMV. Outcomes compare changes in strength, mobility, weaning success and discharge home from a long-term acute care hospital (LTACH) between the groups.ResultsEighteen males and 14 females (age 60.3 ± 11.9 years) who received PMV for ≥14 days were enrolled. Despite no significant differences between groups in the changes in handgrip, gait speed, short physical performance battery or 6-min walk distance after treatment, the MRP + UC group had greater weaning success (87% vs. 41%, p < 0.01), and more patients discharged home than UC (53 vs. 12%, p = 0.05). Post hoc analyses, combining patients based on successful weaning or discharge home, demonstrated significant improvements in strength, ambulation and mobility.ConclusionThe addition of an MRP that improves strength, physical function and mobility to usual physical therapy in LTACH patients with ICUAW is associated with greater weaning success and discharge home than UC alone.Copyright © 2018 Elsevier Inc. All rights reserved.

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