• Trevor J B Dummer, Philip Awadalla, Catherine Boileau, Camille Craig, Isabel Fortier, Vivek Goel, Jason M T Hicks, Sébastien Jacquemont, Bartha Maria Knoppers, Nhu Le, Treena McDonald, John McLaughlin, Anne-Marie Mes-Masson, Anne-Monique Nuyt, Lyle J Palmer, Louise Parker, Mark Purdue, Paula J Robson, John J Spinelli, David Thompson, Jennifer Vena, Ma'n Zawati, and with the CPTP Regional Cohort Consortium.
• School of Population and Public Health (Dummer), University of British Columbia, Vancouver, BC; Ontario Institute for Cancer Research (Awadalla); CARTaGENE (Boileau), Montréal, Que.; Research Institute of the McGill University Health Centre (Craig, Fortier); Research and Innovation, University of Toronto (Goel); Ontario Agency for Health Protection and Promotion (Goel); Atlantic PATH, Dalhousie University (Hicks), Halifax, NS; Centre hospitalier universitaire Sainte-Justine (Jacquemont); Centre of Genomics and Policy, McGill University (Knoppers, Zawati), Montréal, Que.; BC Cancer Research Centre (Le, McDonald), Vancouver, BC; Public Health Ontario (McLaughlin), Toronto, Ont.; Institut du cancer de Montréal, Université de Montréal (Mes-Masson); Pediatrics, CHU Sainte-Justine Research Center (Nuyt), Montréal, Que.; School of Public Health, University of Adelaide (Palmer), Adelaide, Australia; Department of Medicine, Dalhousie University (Parker); Division of Cancer Epidemiology and Genetics, National Cancer Institute (Purdue), Bethesda, Md.; CancerControl Alberta, Alberta Health Services (Robson, Vena), Edmonton, Alta.; Population Oncology, BC Cancer (Spinelli), Vancouver, BC; Atlantic PATH, Dalhousie University (Thompson), Halifax, NS trevor.dummer@ubc.ca.
• CMAJ. 2018 Jun 11; 190 (23): E710-E717.

BackgroundUnderstanding the complex interaction of risk factors that increase the likelihood of developing common diseases is challenging. The Canadian Partnership for Tomorrow Project (CPTP) is a prospective cohort study created as a population-health research platform for assessing the effect of genetics, behaviour, family health history and environment (among other factors) on chronic diseases.MethodsVolunteer participants were recruited from the general Canadian population for a confederation of 5 regional cohorts. Participants were enrolled in the study and core information obtained using 2 approaches: attendance at a study assessment centre for all study measures (questionnaire, venous blood sample and physical measurements) or completion of the core questionnaire (online or paper), with later collection of other study measures where possible. Physical measurements included height, weight, percentage body fat and blood pressure. Participants consented to passive follow-up through linkage with administrative health databases and active follow-up through recontact. All participant data across the 5 regional cohorts were harmonized.ResultsA total of 307 017 participants aged 30-74 from 8 provinces were recruited. More than half provided a venous blood sample and/or other biological sample, and 33% completed physical measurements. A total of 709 harmonized variables were created; almost 25% are available for all participants and 60% for at least 220 000 participants.InterpretationPrimary recruitment for the CPTP is complete, and data and biosamples are available to Canadian and international researchers through a data-access process. The CPTP will support research into how modifiable risk factors, genetics and the environment interact to affect the development of cancer and other chronic diseases, ultimately contributing evidence to reduce the global burden of chronic disease.© 2018 Joule Inc. or its licensors.

28 keywords...

hide…