• Hyo Joon Kim, Kyu Nam Park, Soo Hyun Kim, Byung Kook Lee, Sang Hoon Oh, Hyung Ki Moon, Kyung Woon Jeung, Seung Pill Choi, In Soo Cho, and Chun Song Youn.
• Department of Emergency Medicine, Seoul St. Mary Hospital, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of Korea.
• J Crit Care. 2018 Oct 1; 47: 227-231.

PurposeThis study aimed to elucidate the association between the neutrophil-to-lymphocyte ratio (NLR) and neurological outcomes in out-of-hospital cardiac arrest (OHCA) patients treated with targeted temperature management (TTM).Materials And MethodsA retrospective study was performed on patients treated with TTM after OHCA. Patients were divided into two groups according to their calculated NLRs (NLR < 6 and NLR ≥ 6). The primary outcome was poor neurological outcome at 6 months as defined by a Cerebral Performance Category between 3 and 5.ResultsA total of 216 were included and 131 subjects had poor neurological outcomes at 6 months. In the univariate model, NLRs ≥ 6 at 48 and 72 h after ROSC were associated with poor neurological outcomes (OR: 3.716, 95% CI: 1.243-11.114; OR: 7.429, 95% CI: 3.693-14.945, respectively). In the multivariate logistic regression analysis, an NLR ≥ 6 at 72 h was associated with poor neurological outcomes after adjusting for history of HTN, shockable rhythm, cardiac cause of arrest and time from collapse to ROSC and highest WBC, hs-CRP, lactate and pneumonia (OR = 3.299, 95% CI = 1.080-10.081).ConclusionsAn NLR ≥ 6 at 72 h after the ROSC is associated with poor neurological outcomes at 6 months after CA.Copyright © 2018 Elsevier Inc. All rights reserved.

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