• Takayuki Otani, Hirotaka Sawano, Tomoaki Natsukawa, Tetsufumi Nakashima, Hiroshi Oku, Chison Gon, Motonori Takahagi, and Yasuyuki Hayashi.
• Senri Critical Care Medical Center, Osaka Saiseikai Senri Hospital, 1-1-6, Tsukumodai, Suita-city, Osaka 565-0862, Japan. Electronic address: sonnyboy@tempo.ocn.ne.jp.
• J Crit Care. 2018 Dec 1; 48: 15-20.

ProposeThe aim of this retrospective study was to investigate the prognostic factors in extracorporeal cardiopulmonary resuscitation (ECPR) patients and to assess their accuracy as predictors of a favorable neurological outcome.Materials And MethodsBetween October 2009 and December 2017, we retrospectively analyzed witnessed out-of-hospital cardiac arrest patients who were admitted to our hospital and resuscitated with ECPR. We compared the baseline characteristics, pre-hospital clinical course, arrest causes, and blood samples on admission for the favorable and unfavorable outcome groups.ResultsAmong the 135 patients included, 22 (16%) had a favorable neurological outcome. Low-flow time was shorter (median 38 vs. 48 min, p < 0.001) in the favorable neurological outcome group; in multiple logistic analyses, low-flow time was significantly associated with a favorable neurological outcome (odds ratio, 0.88; 95% confidence interval, 0.82-0.94). The area under the receiver-operating characteristic curve of low-flow time was 0.80 (95% confidence interval, 0.70-0.89), and the cut-off value of 58 min corresponded to a sensitivity of 0.25 and a specificity of 1.0.ConclusionsIn ECPR patients, low-flow time was significantly associated with a favorable neurological outcome, and ECPR should be performed within 58 min of the low-flow time.Copyright © 2018 Elsevier Inc. All rights reserved.

20 keywords...

hide…