• Jessica A Palakshappa, John P Reilly, William D Schweickert, Brian J Anderson, Viviane Khoury, Michael G Shashaty, David Fitzgerald, Caitlin Forker, Kelly Butler, Caroline A Ittner, Rui Feng, D Clark Files, Michael P Bonk, Jason D Christie, and Nuala J Meyer.
• Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA; Section of Pulmonary, Critical Care, Allergy, and Immunologic Diseases, Wake Forest Baptist Health, Winston-Salem, NC 27157, USA. Electronic address: jpalaksh@wakehealth.edu.
• J Crit Care. 2018 Oct 1; 47: 324330324-330.

PurposeThe objective of this study is to describe the relationship between two quantitative muscle ultrasound measures, the rectus femoris cross-sectional area (RF-CSA) and quadriceps muscle thickness, with volitional measures of strength and function in critically ill patients with sepsis.Materials And MethodsWe performed a prospective study of patients admitted to a medical ICU with sepsis and shock or respiratory failure. We examined the association of two ultrasound measurements - the RF-CSA and quadriceps muscle thickness - with strength and function at day 7. Strength was determined using the Medical Research Council Score and function using Physical Function in the ICU Test, scored.ResultsTwenty-nine patients were enrolled; 19 patients had outcome testing performed. Over 7days, RF-CSA and thickness decreased by an average of 23.2% and 17.9%, respectively. The rate of change per day of RF-CSA displayed a moderate correlation with strength (ρ 0.51, p-value 0.03) on day 7. Baseline and day 7 RF-CSA did not show a significant correlation with either outcome. Quadriceps muscle thickness did not significantly correlate with either outcome.ConclusionsMuscle atrophy as detected by the rate of change in RF-CSA moderately correlated with strength one week after sepsis admission.Copyright © 2018 Elsevier Inc. All rights reserved.

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