• Matteo Parotto, Jane Batt, and Margaret Herridge.
• Department of Anesthesia, University of Toronto, 123 Edward Street, Toronto, ON M5G 1E2, Canada; Department of Anesthesia and Pain Management, Toronto General Hospital, EN 442 - 200 Elizabeth Street, Toronto, ON M5G 2C4, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, 209 Victoria Street, Toronto, ON M5B 1T8, Canada. Electronic address: matteo.parotto@uhn.ca.
• Crit Care Clin. 2018 Oct 1; 34 (4): 549-556.

AbstractDisability after critical illness is heterogeneous and related to multiple morbidities. Muscle and nerve injury represent prevalent and important determinants of long-term disability. As the population ages and accrues a greater burden of comorbid illness and medical complexity, those patients admitted to an intensive care unit will be challenged in their recovery because of diminished organ reserve and variable tissue resiliency. This represents a significant burgeoning public health concern. This article presents a brief overview of the pathophysiology and the emerging basic science of neuromuscular dysfunction in critical illness.Copyright © 2018 Elsevier Inc. All rights reserved.

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