• Critical care clinics · Oct 2018

    Review

    Intensive Care Nutrition and Post-Intensive Care Recovery.

    • Jan Gunst and Greet Van den Berghe.
    • Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
    • Crit Care Clin. 2018 Oct 1; 34 (4): 573-583.

    AbstractIntensive care unit (ICU)-acquired weakness frequently complicates critical illness, which prolongs intensive care dependency and causes long-term burden. Observational studies have suggested that prolonged underfeeding could aggravate ICU-acquired weakness and impair outcome. However, recent large randomized controlled trials have failed to show a benefit of early enhanced nutrition to critically ill patients. Moreover, early parenteral nutrition was even shown to increase ICU-acquired weakness and prolong organ failure and intensive care dependency, which may be explained by feeding-induced suppression of autophagy. Currently, the ideal timing of artificial nutrition for critically ill patients as well as the optimal dose and composition remain unclear.Copyright © 2018 Elsevier Inc. All rights reserved.

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