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Critical care clinics · Oct 2018
ReviewSedation, Delirium, and Cognitive Function After Critical Illness.
- Timothy D Girard.
- Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 638 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA. Electronic address: timothy.girard@pitt.edu.
- Crit Care Clin. 2018 Oct 1; 34 (4): 585-598.
AbstractDelirium has been consistently identified as a risk factor for critical illness brain injury, but ICU patients are exposed to a multitude of risk factors for delirium and it remains unclear which of these risk factors should be targeted to improve long-term cognitive outcomes. Because exposure to sedating medications-which are frequently used to treat unwanted yet common symptoms during critical illness-is a risk factor for delirium that is directly controlled by clinicians, the relationship between sedation, delirium, and long-term cognition is of great interest to clinicians, researchers, and patients. This review describes theoretic relationships between sedation, delirium, and long-term cognition and reviews the evidence supporting these theoretic relationships.Copyright © 2018 Elsevier Inc. All rights reserved.
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