• Curr Opin Anaesthesiol · Feb 2018

    Review

    Vitamin C in sepsis.

    • Sven-Olaf Kuhn, Konrad Meissner, Lena M Mayes, and Karsten Bartels.
    • Klinik für Anästhesiologie, Universitätsmedizin Greifswald, Greifswald, Germany.
    • Curr Opin Anaesthesiol. 2018 Feb 1; 31 (1): 556055-60.

    Purpose Of ReviewThis narrative review summarizes recent insights into the role of vitamin C in sepsis.Recent FindingsSeptic shock remains a major source of morbidity and mortality in critically ill patients. Although many nutritional supplements have previously been tested unsuccessfully, vitamins are still being explored as a therapeutic option in septic patients. In particular, vitamin C-containing regimens as adjunctive therapy in sepsis have received much attention.SummaryIn-vitro evidence supports a critical role for vitamin C in cellular mechanisms relevant to the pathophysiology of sepsis. However, whether this justifies therapeutic use of vitamin C in septic patients remains uncertain.

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