• Clin J Pain · Nov 2018

    Review

    An Update on the Basic and Clinical Science of Ketamine Analgesia.

    • Lisa V Doan and Jing Wang.
    • Departments of Anesthesiology, Perioperative Care and Pain Medicine.
    • Clin J Pain. 2018 Nov 1; 34 (11): 1077-1088.

    ObjectiveIn the context of the current opioid epidemic, there has been a renewed interest in the use of ketamine as an analgesic agent.MethodsWe reviewed ketamine analgesia.ResultsKetamine is well-known as an antagonist for N-methyl-D-aspartate receptors. In addition, it can regulate the function of opioid receptors and sodium channels. Ketamine also increases signaling through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors. These myriad of molecular and cellular mechanisms are responsible for a number of pharmacological functions including pain relief and mood regulation. Clinically, a number of studies have investigated the role of ketamine in the setting of acute and chronic pain, and there is evidence that ketamine can provide analgesia in a variety of pain syndromes.DiscussionIn this review, we examined basic mechanisms of ketamine and its current clinical use and potential novel use in pain management.

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